Who Has The Most Home Runs In The Mlb 2025?. Players in bold face are active as of the 2025 major league baseball season (including free agents), with the number in parentheses. Barry bonds holds the record for the most home runs in one season, with a whopping 73 home runs hit in the 2001 season.
Removing the shortened 2020 pandemic season, alonso has hit at least 34 home runs every year, and walker has crossed that threshold just once (36 home runs in 2022). Giancarlo stanton has launched the most career homers by an active player, with 429 home runs.
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